Theory, simulations, and experiments show that proteins fold by multiple pathways
نویسندگان
چکیده
منابع مشابه
Simulations Show That Shame Drives Social Cohesion
Using the agent based simulation model Sociodynamica, I explore the effect of various intensities of feelings of shame in cementing social bonds that affect the aggregate health (average longevity of agents) and wealth (GDP) of two artificial societies: A primitive society with no division of labor, and a monetized society with division of labor for three different tasks. The results show that ...
متن کاملHow to fold intricately: using theory and experiments to unravel the properties of knotted proteins.
Over the years, advances in experimental and computational methods have helped us to understand the role of thermodynamic, kinetic and active (chaperone-aided) effects in coordinating the folding steps required to achieving a knotted native state. Here, we review such developments by paying particular attention to the complementarity of experimental and computational studies. Key open issues th...
متن کاملFold assembly of small proteins using monte carlo simulations driven by restraints derived from multiple sequence alignments.
The feasibility of predicting the global fold of small proteins by incorporating predicted secondary and tertiary restraints into ab initio folding simulations has been demonstrated on a test set comprised of 20 non-homologous proteins, of which one was a blind prediction of target 42 in the recent CASP2 contest. These proteins contain from 37 to 100 residues and represent all secondary structu...
متن کاملExperiments and simulations show how long-range contacts can form in expanded unfolded proteins with negligible secondary structure.
The sizes of unfolded proteins under highly denaturing conditions scale as N(0.59) with chain length. This suggests that denaturing conditions mimic good solvents, whereby the preference for favorable chain-solvent interactions causes intrachain interactions to be repulsive, on average. Beyond this generic inference, the broader implications of N(0.59) scaling for quantitative descriptions of d...
متن کاملTemperature Effect on Mechanical Properties of Top Neck Mollusk Shells Nano-Composite by Molecular Dynamics Simulations and Nano-Indentation Experiments
Discovering the mechanical properties of biological composite structures at the Nano-scale is much interesting today. Top Neck mollusk shells are amongst biomaterials Nano-Composite that their layered structures are composed of organic and inorganic materials. Since the Nano indentation process is known as an efficient method to determine mechanical properties like elastic modulus and hardness ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2017
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1716444114